产品名称 Recombinant Rat Cellular tumor antigen p53 (Tp53) from BIOMATIK
产品货号 RPC20212
产品价格 现货询价,电话:010-67529703
产品规格 100ug
产品品牌 BIOMATIK
产品概述
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Product NameRecombinant Rat Cellular tumor antigen p53 (Tp53)
DescriptionPurity > 90% as determined by SDS-PAGE. MW: 47.5kDa. Full Length: 1-391aa. N-terminal 6xHis-tagged. Rattus norvegicus (Rat). Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction ses to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and se to have to effect on cell-cycle regulation. Regulates the circadian clock by repressing CLOCK-ARNTL/BMAL1-mediated transcriptional activation of PER2.
Size100ug
Concentrationn/a
ApplicationsRUO
Other NamesTumor suppressor p53
Gene, Accession, CAS #Tp53, UniProt: P10361
Catalog #RPC20212
Price
Order / More InfoRecombinant Rat Cellular tumor antigen p53 (Tp53) from BIOMATIK
Product Specific Referencesn/a
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