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| Product Name | Recombinant Rat Chemokine (C-C motif) ligand 24 protein (Ccl24) (Active) |
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| Description | Purity > 95% as determined by SDS-PAGE. MW: 21kDa. Partial: 29-216aa. C-terminal 6xHis-tagged. Homo sapiens (Human). OX40, also termed CD134 and TNFRSF4, is a T cell co-stimulatory molecule of the TNF receptor superfamily which plays a key role in the survival and homeostasis of effector and memory T cells. OX40 is expressed on CD4+ and CD8+ T cells upon engagement of the TCR by antigen presenting cells along with co-stimulation by CD40-CD40 Ligand and CD28-B7. The interaction between OX40 and OX40 ligand (OX40L) will occur when activated T cells bind to professional antigen-presenting cells (APCs). The T-cell functions, including cytokine production, expansion, and survival, are then enhanced by the OX40 costimulatory signals. OX40 signals are critical for controlling the function and differentiation of Foxp3+ regulatory T cells. OX40-OX40L interaction regulates T-cell tolerance, peripheral T-cell homeostasis, and T-cell-mediated inflammatory diseases. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | Tumor necrosis factor receptor superfamily member 4; TNFRSF4; OX40; CD134; Txgp1 |
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| Gene, Accession, CAS # | TNFRSF4, UniProt: P43489 |
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| Catalog # | RPC26970 |
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| Order / More Info | Recombinant Rat Chemokine (C-C motif) ligand 24 protein (Ccl24) (Active) from BIOMATIK |
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| Product Specific References | n/a |
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