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| Product Name | Recombinant Mouse TNFSF18 (GITRL) (carrier-free) |
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| Description | The mouse TNFSF18 (GITRL) ligand was initially cloned from mouse endolthelioma cells. It is a type II membrane protein consisting of 173 amino acids and is 51% identical to the human protein. In contrast to the homotrimeric structure of the TNF family members, the mouse GITRL crystal structure reveals a dimeric assembly. GITR is a costimulatory molecule and is a member of the TNF growth factor receptor family, which includes CD40, CD27, 4-1BB, and OX40. GITRL is induced on murine splenic B cells by LPS, CpG oligonucleotide, and IL4 + CD40. GITRL is also induced in retinal pigment epithelial cells by IL-1α, TNFα, and IFNγ. GITRL interacts with soluble GITR and initiates the immune regulation of tryptophan catabolism through reverse signaling in mouse plasmacytoid dendritic cells. Also, GITRL reverse signaling upregulates inducible nitric oxide synthase (iNOS) in murine macrophages. GITRL is expressed on mouse and human keratinocytes and its expression can be induced by Th2 cytokines in mouse keratinocytes. The induction of GITRL in human keratinocytes is mediated by Th2 cytokines and TNFα. GITRL expression is upregulated in keratinocytes from acute atopic dermatitis (AD) compared with normal skin or inflamed lesions from chronic AD. |
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| Size | 10 µg |
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| Concentration | n/a |
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| Applications | BA |
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| Other Names | Activation-inducible TNF receptor (AITR) ligand (AITRL), GITR ligand, GITRL |
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| Gene, Accession, CAS # | Gene ID: 240873 |
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| Catalog # | 752602 |
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| Order / More Info | Recombinant Mouse TNFSF18 (GITRL) (carrier-free) from BIOLEGEND |
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| Product Specific References | n/a |
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