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| Product Name | LINGO, 241-337aa, Human, His tag, E.coli (Denatured) |
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| Description | Purity: > 90% by SDS - PAGE Format: Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 10% glycerol. Lingo1 also known as Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein1. LINGO-1 is primarily expressed in neuronal tissue, and most abundantly in cortex. It has been implicated in the inhibition of axon regeneration through a ternary complex formed with NgR1 (ligand-binding subunit) and p75 (signal transducing subunit). The inhibitory action is achieved through RhoA-GTP upregulation in response to the presence of MOG, MAG or Nogo-66 in the central nervous system. LINGO-1 also inhibits oligodendrocyte precursor differentiation and myelination, by a mechanism that also involves activation of RhoA, but which apparently does not require 75 or NgR1.Recombinant human LINGO1 protein, was expressed in E.coli |
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| Size | 0.5mg, 100ug, 20ug |
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| Concentration | n/a |
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| Applications | SDS-PAGE |
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| Other Names | Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein1, LERN1, LRRN6A, uNQ201 |
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| Gene, Accession, CAS # | NP 116197 |
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| Catalog # | ATGP3011 |
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| Order / More Info | LINGO, 241-337aa, Human, His tag, E.coli (Denatured) from ATGen |
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| Product Specific References | n/a |
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