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| Product Name | Recombinant Human CD14 (carrier-free) |
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| Description | CD14 is a pattern recognition receptor important in innate immunity. CD14 exists in two forms, as a glycosylphosphatidylinositol-anchored protein on the surface of mononuclear cells and as a soluble protein in the blood. CD14 is shed from the surface of CD14-expressing cells, resulting in the soluble CD14 protein (sCD14). CD14 is down regulated from the cell membrane on stimulated monocytes by different factors such as LPS, IFNγ, PMA, calcium ionophore A 23187, and antibodies against CD14. CD14 can be released from the cells with GPI-phospholipase C and D (PLC/D). Membrane associated CD14 is a pro-inflammatory coreceptor for LPS, a characteristic constituent of the cell wall of Gram-negative bacteria. LPS interacts with LPS-binding protein (LBP) and CD14, and this complex interacts with TLR4, which subsequently induces inflammatory gene expression through NF-κB and mitogen-activated protein-kinase signaling in host cells. sCD14 enables responses to LPS by cells that do not express CD14 such as endothelial cells. In this sense, HUVEC cells respond to LPS by production of IL-6 and this responsiveness is serum dependent. Elevated levels of sCD14 has been detected in serum of patients with different diseases such as systemic lupus erythematosus, HIV infected patients, common variable immunodeficiency (CVID), and nonalcoholic fatty liver disease (NAFLD). Also, high levels of sCD14 has been associated with infectious diseases, including sepsis. In addition, it has been reported that sCD14 could be a potential biomarker for predicting the prognosis of breast invasive ductal carcinoma. |
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| Size | 100 µg |
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| Concentration | n/a |
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| Applications | BA |
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| Other Names | Human monocyte differentiation antigen CD14, Myeloid cell-specific leucine-rich glycoprotein. |
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| Gene, Accession, CAS # | Gene ID: 929 |
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| Catalog # | 593006 |
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| Order / More Info | Recombinant Human CD14 (carrier-free) from BIOLEGEND |
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| Product Specific References | n/a |
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