| 产品详情 |
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| Antigenic Specificity | TCF12 |
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| Clone | W16168A |
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| Host Species | Rat |
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| Reactive Species | human |
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| Isotype | IgG2b, κ |
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| Format | purified |
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| Size | 100 µg |
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| Concentration | n/a |
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| Applications | Western Blot (WB) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Purified anti-TCF12. TCF12, also known as HTF4 or HEB, is a member of class I basic helix-loop-helix (bHLH) protein family that recognizes the consensus E-box (5'-CANNTG-3') DNA binding site. TCF12 is a transcription factor that participates in regulating gene expression through formation of homodimer or heterodimers with other bHLH E-proteins. TCF12 has been shown to be involved in neuron differentiation and is upregulated in certain cancer cells. TCF12 functions as a transcriptional repressor responsible for down-regulating expression of E-cadherin in colorectal cancer cells. TCF12-deficient mice show abnormality in brain development and a high percentage of postnatal death. Mutations in TCF12 gene have been linked to coronal craniosynostosis. |
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| Immunogen | Human TCF12 recombinant protein (108-521 a.a.) expressed in E. coli. |
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| Other Names | Transcription factor 12, Class B basic helix-loop-helix protein 20 (bHLHb20), HEB, HTF4 |
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| Gene, Accession # | Gene ID: 6938 |
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| Catalog # | 698702 |
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| Price | |
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| Order / More Info | TCF12 Antibody from BIOLEGEND |
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| Product Specific References | n/a |
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