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| Product Name | LEGEND MAX™ Total TGF-β1 ELISA Kit with Pre-coated Plates |
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| Description | Transforming growth factor beta 1 (TGF-β1) is a member of the transforming growth factor beta superfamily of cytokines. TGF-ß1 precursor contains 390 amino acids with an N-terminal signal peptide of 29 amino acids required for secretion from a cell, a 249 amino acids pro-region ( latency associated peptide or LAP), and a 112 amino acids C-terminal region that becomes the active TGF-β 1 upon activation.Both LAP and TGF-ß1 exist as homodimers in circulation, but the disulfide linked homodimers of LAP and TGF-β1 remain non-covalently associated, forming the small latent TGFβ1 complex (SLC, 100 kD). The large latent TGF- β1 Complex (LLC, 235 – 260 kD) contains a third component, the latent TGF- β binding protein (LTBP), which is linked to LAP by a single disulfide bond. The LTBP does not confer latency, but for efficient secretion of the complex to extracellular sites. Free active TGF-β1 can be released (activated) by many factors including enzymes and low or high pH.TGF-β1 is nearly 100% conserved across mammalian species. It has diverse biological functions in multiple cellular processes such as regulating proliferation and differentiation of various cell types. TGF-ß1 is also an important immunoregulatory cytokine, which is involved in the maintenance of self-tolerance, Th17 differentiation, and T cell homeostasis etc. |
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| Size | 1 Pre-coated Plate |
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| Concentration | ELISA |
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| Applications | n/a |
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| Other Names | Tgfb-1, Tgfb1, Tgf-b1, Tgfb-1, TGFbeta1, TGF-beta1, TGF beta 1, TGFβ Precoated ELISA Kit |
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| Gene, Accession, CAS # | Gene ID: 21803 |
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| Catalog # | 436707 |
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| Order / More Info | LEGEND MAX™ Total TGF-β1 ELISA Kit with Pre-coated Plates from BIOLEGEND |
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| Product Specific References | PubMed: 24569586,25056699 |
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