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| Product Name | Recombinant Mouse MMP-3 (carrier-free) |
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| Description | MMP-3 is a member of the matrix metalloproteinase family proteins (MMPs). MMPs are structurally related, zinc-containing enzymes that degrade the extracellular matrix (ECM) and connective tissue proteins in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling as well as in disease processes such as arthritis and metastasis. MMP-3 consists of a prodomain which is cleaved upon activation, a catalytic domain containing the zinc binding site, a short hinge region, and a carboxyl terminal (Hemopexin-like repeats) domain. Substrates of MMP-3 include collagen α chains, aggrecan, laminin, fibronectin, elastin, casein, α1-antitrypsin, myelin basic protein, IL-1β, IGFBP3, pro MMP-1, pro MMP-7, pro MMP-8, pro MMP-9, and pro MMP-13. MMP-3 is thought to be involved in wound repair, progression of atherosclerosis, and tumor initiation. It has been described that a polymorphism in the MMP-3 promoter region is associated with the risk of coronary heart disease and myocardial infarction, due to lower MMP-3 proteolytic activity and higher ECM deposition in atherosclerotic lesions. MMP-3 knockout mice have reduced vascular smooth muscle cell accumulation in atherosclerotic plaques, indicating that MMP-3 plays a role in neointima formation. |
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| Size | 10 µg |
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| Concentration | n/a |
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| Applications | BA |
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| Other Names | Stromelysin-1, Transin-1, Progelatinase, MMP3 |
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| Gene, Accession, CAS # | Gene ID: 17392 |
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| Catalog # | 552702 |
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| Order / More Info | Recombinant Mouse MMP-3 (carrier-free) from BIOLEGEND |
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| Product Specific References | n/a |
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