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| Product Name | Recombinant Human IL-17A (ELISA Std.) |
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| Description | IL-17A is the founding member of the IL-17 family, a group of six structurally related pro-inflammatory cytokines. IL-17A, secreted by activated CD4+ Th17 cell subpopulation, elicits multiple biological activities on a variety of cells including: the induction of IL-6, IL-8, G-CSF, and PGE2 production in epithelial, endothelial or fibroblasts; the enhancement of surface expression of ICAM-1 in fibroblasts; activation of NF-κB and costimulation of T cell proliferation. Recent studies demonstrated that, in mice, activated IL-17-secreting CD4+ helper T cells (Th17 cells)mediate an autoimmune arthritis that clinically and immunologically resembles rheumatoid arthritis (RA).Human IL-17A shows 63%, 63% and 72% amino acid sequence identity to rat IL-17A, mouse IL-17A and a protein encoded by the ORF13 gene of herpesvirus Saimiri (HVS), respectively.Both recombinant and natural IL-17A have been shown to exist as a disulfide-linked homodimeric glycoprotein containing two ~16 kD monomers. |
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| Size | 4 pack |
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| Concentration | n/a |
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| Applications | ELISA |
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| Other Names | Interleukin-17A |
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| Gene, Accession, CAS # | Gene ID: 3605 |
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| Catalog # | 570509 |
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| Price | |
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| Order / More Info | Recombinant Human IL-17A (ELISA Std.) from BIOLEGEND |
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| Product Specific References | n/a |
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