| 产品详情 |
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| Product Name | PF-562271 |
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| Description | Purity ≥95%. Potent ATP-competitive reversible inhibitor of FAK and Pyk2. PF-562,271 is a potent, ATP-competitive, reversible inhibitor of FAK and Pyk2 catalytic activity with a IC(50) of 1.5 and 14nm, respectively. In addition, PF-562,271 displayed robust inhibition in an inducible cell-based assay measuring phospho-FAK with an IC(50) of 5nm. PF-562,271 was evaluated against multiple kinases and displays >100X selectivity against a long list of non target kinases. In tests, PF-562,271 inhibits FAK phosphorylation in vivo in a dose-dependent fashion with a calculated EC50 of 93ng/ml using injections. Synonyms: PF562271, N-[3-[[[2-[(2,3-Dihydro-2-oxo-1H-indol-5-yl)amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]methyl]-2-pyridinyl]-N-methyl-methanesulfonamide Hydrochloride |
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| Size | 1mg, 5mg, 10mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | PF562271, N-[3-[[[2-[(2,3-Dihydro-2-oxo-1H-indol-5-yl)amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]methyl]-2-pyridinyl]-N-methyl-methanesulfonamide Hydrochloride |
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| Gene, Accession, CAS # | CAS: 717907-75-0 |
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| Catalog # | 215890 |
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| Order / More Info | PF-562271 from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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