产品详情 |
Edit |   |
Product Name | GSK-J4 (Free base) |
Description | GSK- J4 is cell-permeable ethyl ester of GSK-J1 (Cat. Nos. 2260 & 2761). Acts as a histone demethylase JMJD3/UTX inhibitor. Inhibits demethylation of histone H3K27. Reduces LPS-induced proinflammatory cytokine production in primary human macrophages (IC50 = 9 µM for the inhibition of TNFα release). Rescues newborn pups from embryonic lethality in BRAF knockin mice which recapitulate major features of RASopathies. MW: 417.5. Purity ≥99% by TLC |
Size | 5 mg |
Concentration | n/a |
Applications | n/a |
Other Names | N-[2-(2-Pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]-β-alanine ethyl ester |
Gene, Accession, CAS # | CAS: 1373423-53-0 |
Catalog # | 2762-5 |
Price | |
Order / More Info | GSK-J4 (Free base) from BIOVISION, INC. |
Product Specific References | n/a |
产品资料 |
|
|