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| Product Name | Rac1/Cdc42 Activation Assay Combo Kit |
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| Description | Background: Small GTP-binding proteins (or GTPases) are a family of proteins that serve as molecular regulators in signaling transduction pathways. Rac1 and Cdc42, 21 kDa proteins, belong to the family of Rho GTPases regulates a variety of biological response pathways that include cell motility, cell division, gene transcription, and cell transformation. Like other small GTPases, Rac1 and Cdc42 regulate molecular events by cycling between an inactive GDP-bound form and an active GTP-bound form. |
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| Size | 40 assays |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | MBS168431 |
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| Order / More Info | Rac1/Cdc42 Activation Assay Combo Kit from MYBIOSOURCE INC. |
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| Product Specific References | 1. Raftopoulou M., and Hall A. (2004) Dev Biol. 265: 23-32.2. Bar-Sagi D., and Hall A. (2000) Cell 103: 227-38.3. Benard, V., Bohl, B. P., and Bokoch, G. M. (1999) J. Biol. Chem. 274, 13198-13204.1. Chen, H. et al. (2010). Integrity of SOS1/EPS8/ABI1 Tri-Complex Determines Ovarian Cancer Metastasis. Cancer Res. 70:9979-9990.2. Sultana, H. et al. (2010). Anaplasma Phagocytophilum Induces Actin Phosphorylation to Selectively Regulate Gene Transcription in Ixodes Scapularis Ticks. J. Exp. Med. 10.1084/jem.20100276.3. Pandey, D. et al. (2009). Unraveling a Novel Rac1-Mediated Signaling Pathway that Regulates Cofilin Dephosphorylation and Secretion in Thrombin Stimulated Platelets. Blood 114:415-424.4. Lorger, M. et al. (2006). Regulation of Epithelial Wound Closure and Intercellular Adhesion by Interaction of AF6 with Actin Cytoskeleton. J. of Cell Science 119:3385-3398. |
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