| 产品详情 |
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| Antigenic Specificity | Caspase -12 |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | mouse, rat |
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| Isotype | n/a |
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| Format | affinity purified |
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| Size | 100 µg |
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| Concentration | 0.2 mg/ml |
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| Applications | Western blot |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Caspase-12 Antibody. Three distinct signaling pathways lead to programmed cell death (apoptosis). The death receptor and mitochondrion pathways are the mains two pathways, in which the key apoptotic proteases caspase-8 and caspase-9, respectively, are involved. The endoplasmic reticulum (ER) stress is the third apoptotic pathway and caspase-12 is involved. Caspase-12 is located to the ER, but not to the cytoplasm or mitochondrion. Caspase-12 is activated by ER stress, including disruption of ER calcium hemeostasis, and mediates ER stress-induced apoptosis. Caspase-12 is localized to the ER with several proteins that are involved in Alzheimer's disease including gamma-secretase presenilin and β-amyloid precursor protein (APP). Caspase-1 |
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| Immunogen | Synthetic peptide corresponding to residues surrounding amino acid 310 of mouse caspase-12 |
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| Other Names | CASP12 , CASP12P1 |
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| Gene, Accession # | Gene ID: 12364, Accession: NM_009808 |
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| Catalog # | 3282-100 |
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| Price | |
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| Order / More Info | Caspase -12 Antibody from BIOVISION, INC. |
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| Product Specific References | n/a |
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