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| Product Name | Recombinant Human IL-23 (carrier-free) |
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| Description | Interleukin 23 (IL-23) is a member of the IL-6 family of cytokines, and it is comprised of two subunits, p19 and p40. The p19/p40 heterodimer is stabilized by a disulfide bond. The p40 subunit is shared by IL-23 and IL-12 cytokines. p19 mRNA is expressed in endothelial cells and polarized T cells; p40 is not expressed by these cells. Therefore, the availability of functional IL-23 is limited by the expression of p40 and not p19. IL-23 exerts its biological activities through the interaction with a heterodimeric receptor complex composed of IL-12Rb1 and IL-23R. IL-23 activates Janus kinase (JAK)/signal transducer and activator of transcription (STAT) signaling molecules. JAK2 is constitutively associated with the IL-23R chain, and binding of IL-23 to its receptor leads to phosphorylation of STAT1, STAT3, STAT4, and STAT5. |
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| Size | 25 µg |
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| Concentration | n/a |
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| Applications | BA |
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| Other Names | Interleukin 23 (Interleukin 23, alpha subunit p19 and Interleukin-12 subunit beta p40) |
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| Gene, Accession, CAS # | Gene ID: 3593, 51561 |
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| Catalog # | 574104 |
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| Price | |
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| Order / More Info | Recombinant Human IL-23 (carrier-free) from BIOLEGEND |
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| Product Specific References | n/a |
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