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| Product Name | PHA 665752 |
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| Description | Potent, selective and ATP-competitive inhibitor of MET kinase (IC50 values are 9, 68, 200, 1400, 3000, 3800 and 6000 nM for MET, Ron, Flk-1, c-abl, FGFR1, EGFR and c-src respectively and > 10000 nM for IGF-IR, PDGFR, AURORA2, PKA, PKBα, p38α, MK2 and MK3). Antitumor agent; inhibits tumorigenicity and angiogenesis in mouse lung cancer xenografts. Purity 98%. MW (observed): 641.61 |
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| Size | 50 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | (2R)-1-[[5-[(Z)-[5-[[(2,6-Dichlorophenyl)methyl]sulfonyl]-1,2-dihydro-2-oxo-3H-indol-3-ylidene]methyl]-2,4-dimethyl-1H-pyrrol-3-yl]carbonyl]-2-(1-pyrrolidinylmethyl)pyrrolidine |
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| Gene, Accession, CAS # | CAS: 477575-56-7 |
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| Catalog # | 2693/50 |
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| Price | |
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| Order / More Info | PHA 665752 from TOCRIS BIOSCIENCE
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| Product Specific References | PubMed: 18559453, 19152687, 19380521, 19472407, 20354140, 20841479, 20852387, 20852388, 21151472, 21245936, 21266357, 21464397, 21730976, 21775521, 21847121, 21962244, 22278715, 22895339, 23028720, 23598276, 23792586, 23794705, 23832667, 24052949, 24762959, 25323938, 25884729, 25905717, 26033355, 26310485, 26788066, 26871947 |
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