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| Product Name | Biliverdin Reductase, Recombinant, Rat (BVR) |
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| Description | Lysate. Biliverdin reductase (BVR), Heme oxygenase (HO) and UDP-glucuronosyltransferases (UGTs) form the major erythrocytic heme catabolic pathway in humans and most mammalian species. BVR is an oxireductase which catalyzes the reduction of the gama-meso bridge of biliverdin to bilirubin. Recent studies indicate that BVR is a phosphoprotein and that phosphorylation is essential to the activity of BVR to reduce biliverdin to bilirubin. These studies also found that the enzyme is autophosphorylated and that phosphorylation is reversible. In mammals bilirubin can be both a neurotoxin and an antioxidant depending on its ratio to protein and concentration; has immunomodulatory properties; induces Aryl hydrocarbon receptor-mediated activation of cytochrome P450 1a1 expression and inhibits protein phosphorylation (1). BVR is unique among all enzymes characterized to date because BVR has dual pH/dual cofactor requirements. The reductase is highly conserved in its primary structure and molecula |
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| Size | 20ug |
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| Concentration | n/a |
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| Applications | WB |
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| Other Names | n/a |
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| Gene, Accession, CAS # | SwissProt: P46844 |
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| Catalog # | B1175 |
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| Order / More Info | Biliverdin Reductase, Recombinant, Rat (BVR) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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