| 产品详情 |
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| Product Name | Rab5 (Member RAS Oncogene Family, Ras-related Protein Rab-5, Rab GTPase) |
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| Description | Purity ~90%. Rab5 is a 24kDa member of the Rab family of small guanosine triphosphatases (GTPases), Ras superfamily. Rab GTPases are central regulators of membrane trafficking in the eukaryotic cell. Their regulatory capacity depends on their ability to cycle between the GDP -bound inactive and GTP- bound active states. This conversion is regulated by GDP/GTP exchange factors (GEPs), GDP dissociation inhibitors (GDIs) and GTPase-activating proteins (GAPs) (1, 2). Activation of a Rab protein is coupled to its association with intracellular membranes, allowing it to recruit downstream effector proteins to the cytoplasmic surface of a subcellular compartment (3). Through these proteins, Rab GTPases regulate vesicle formation, actin- and tubulin-dependent vesicle movement, and membrane fusion(1). Rab proteins contain conserved regions involved in guanine-nucleotide binding, and hypervariable COOH-terminal domains with a cysteine motif implicated in subcellular targeting. Post-translational |
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| Size | 50ug, 100ug |
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| Concentration | n/a |
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| Applications | WB |
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| Other Names | n/a |
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| Gene, Accession, CAS # | Accession: BC001267 |
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| Catalog # | R0008-01E |
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| Price | |
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| Order / More Info | Rab5 (Member RAS Oncogene Family, Ras-related Protein Rab-5, Rab GTPase) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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