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| Product Name | Recombinant Human ICAM-2 (carrier-free) |
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| Description | ICAM-2 is a type I transmembrane glycoprotein containing two extracellular Ig superfamily domains, a hydrophobic transmembrane region, and a short cytoplasmic domain, constitutively expressed on various cell types including T and B lymphocytes, macrophages, NK cells, monocytes, dendritic cells, neutrophils, endothelial cells, platelets, and CD34+ hematopoietic progenitor cells. Primarily localized to apical surface near intercellular junctions, ICAM-2 mediates cell binding to integrins like LFA-1 (αLβ2, CD11a/Cd18) and MAC-1 (αMβ2, CD11b/CD18) with strong implications in angiogenesis, inflammation, and cell survival. Specifically, it plays an essential role in lymphocyte adhesion, recruitment, trafficking, recirculation, and extravasation. ICAM-2 associates with ERM (ezrin/radixin/moesin) proteins to activate PI3K/Akt pathway and subsequently inhibit apoptosis in leukocytes and fibroblasts, while promoting capillary tube formation and junction maturation in endothelial cells via triggering of small GTPase Rac1activation. ICAM-2 is the only member of all ICAMs that maps to chromosome 17q23-25, a segment known for genomic instability and high aberration in cancers. ICAM-2 is refractory to pro-inflammatory cytokines such as IL-1, TNF-α, and IFN-γ, the very proteins that strongly upregulate ICAM-1 expression on endothelial cells both in vitro and in vivo. |
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| Size | 100 µg |
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| Concentration | n/a |
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| Applications | BA |
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| Other Names | Intercellular adhesion molecule 2, ICAM2 |
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| Gene, Accession, CAS # | Gene ID: 3384 |
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| Catalog # | 768506 |
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| Order / More Info | Recombinant Human ICAM-2 (carrier-free) from BIOLEGEND |
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| Product Specific References | n/a |
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