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| Product Name | Recombinant Mouse IL-17A (carrier-free) |
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| Description | IL-17A was initially identified from a subtracted cDNA library between closely related murine lymphoid cells and called CTLA-8. IL-17A shares 58% homology with an open reading frame of the T-lymphotropic Herpes virus Samirii virus (viral IL-17). IL-17A belongs to a family of cytokines, which has five members; designated IL-17A-F. IL-17 is expressed by a unique lineage of CD4 T cells, Th17 cells. This lineage selectively produces proinflammatory cytokines including IL-17, IL-17F, IL-21, and IL-22. In the mouse, the differentiation of this new lineage is initiated by TGFbeta-1 and IL-6 or IL-21, which activates Stat3 and induces the expression of the transcription factor retinoic acid-related orphan receptors (RORγt and RORα). IL-23, which also activates Stat3, serves to maintain Th17 cells lineage. |
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| Size | 500 µg |
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| Concentration | n/a |
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| Applications | BA |
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| Other Names | Interleukin-17A, CTLA-8 |
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| Gene, Accession, CAS # | Gene ID: 16171 |
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| Catalog # | 576008 |
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| Order / More Info | Recombinant Mouse IL-17A (carrier-free) from BIOLEGEND |
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| Product Specific References | PubMed: 22156344,22207130,22331300,24412909 |
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