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| Product Name | Recombinant Human CXCL4 (PF-4) (carrier-free) |
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| Description | CXCL4, also known as platelet factor 4 (PF-4), is one of the most abundant platelet chemokines and has several biological functions depending on the cell type. CXCL4 is predominantly synthesized in megakaryocytes, stored in the α-granules of platelets, and released as a tetramer at micromolar concentrations upon platelet activation. CXCL4 has both procoagulant and anticoagulant activities. CXCL4 can bind heparin and neutralize the anticoagulant effect of heparin. On the other hand, CXCL4 inhibits factor XII, and vitamin K dependent coagulation factor, and stimulates activated protein C generation. CXCL4 is a potent tumor inhibitor because it can inhibit endothelial cell migration, proliferation, and in vivo angiogenesis through interfering with the angiogenic effect of growth factors such as FGF and VEGF. CXCL4 binds directly to FGF-β and inhibits its dimerization, which is required for receptor activation. Also, it has been suggested that binding of CXCL4 to polysulfated GAGs can interfere with activation of VEGFR and FGFR. CXCL4 also promotes inflammatory responses. For example, CXCL4 can activate granulocytes and induce monocytes to differentiate into macrophages and antigen-presenting cells. It has been reported that CXCL4 is deposited early in atherosclerotic lesions, and the presence of CXCL4 at atherosclerotic lesions has been associated with plaque progression. Genetic deletion of CXCL4 in Apo-E-/- mice is accompanied with reduced atherogenesis. CXCL4L1, a CXCL4 variant which differs in only three amino acids in its mature form, has been identified. CXCL4 and CXCL4L1 have different subcellular localization and are secreted in a differentially regulated manner. Human CXCL4 binds to CXCR3A and CXCR3B receptor variants, and it should be noted that variant B has not been described in mice. CXCR3A acts as a chemotactic receptor for human cells via CXCL4, and CXCR3B has an antiapoptotic effect in endothelial cells. CXCR3A might be responsible for the chemotactic effect of CXCL4 in mice. |
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| Size | 25 µg |
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| Concentration | n/a |
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| Applications | BA |
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| Other Names | Platelet factor 4, PF4, PF-4, Oncostatin A, Ironplact |
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| Gene, Accession, CAS # | Gene ID: 5196 |
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| Catalog # | 550904 |
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| Order / More Info | Recombinant Human CXCL4 (PF-4) (carrier-free) from BIOLEGEND |
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| Product Specific References | n/a |
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