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| Product Name | Recombinant Human B7-H2-Fc Chimera (carrier-free) |
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| Description | B7-H2 belongs to the B7 family of immunoregulatory molecules and is a transmembrane glycoprotein of approximately 60 kD. Mature human B7-H2 consists of a 238 amino acid extracellular domain (ECD), two immunoglobulin-like domains, a 21 amino acid transmembrane segment, and a 25 residue cytoplasmic domain. Within the ECD, human B7-H2 shares 50% and 54% amino acid sequence identity with mouse and rat B7-H2, respectively. B7-H2 is expressed on antigen presenting cells such as B cells, macrophages, dendritic cells, and also in monocytes. It binds to ICOS and is expressed on activated T cells, which leads to both positive and negative effects on immune responses including its own downregulation. Mouse and human B7-H2 exhibit cross species binding to ICOS. B7-H2 interaction with ICOS is costimulatory for T cell proliferation as well as the development of B cells, plasma cells, follicular helper T cells, and germinal centers. In addition, human B7-H2 binds to CD28 and CTLA4. The interaction of human B7-H2 and CD28 can costimulate both human mouse naïve T cells and regulatory T cells (Treg). B7-H2 plays a role in the development of allergic asthma by enhancing Th2 biased immune responses, limiting Th17 responses, and promoting eosinophilic infiltration into the lungs. B7-H2 activation of ICOS on Tregs limits pulmonary inflammation and airway hyper-responsiveness, promotes the development of inhalational tolerance, and impairs anti-tumor immunity. |
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| Size | 100 µg |
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| Concentration | n/a |
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| Applications | BA |
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| Other Names | B 7 homologe 2 (B7H2), GL50, B7 releated protein 1 (B7RP1), CD275, inducible T cell costimulator ligand ICOS Ligand), LICOS, ICOSLG |
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| Gene, Accession, CAS # | Gene ID: 23308 |
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| Catalog # | 599906 |
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| Order / More Info | Recombinant Human B7-H2-Fc Chimera (carrier-free) from BIOLEGEND |
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| Product Specific References | n/a |
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