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| Product Name | Recombinant Human B7-H4-Fc Chimera (carrier-free) |
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| Description | Human and mouse B7-H4 were identified by homology search in mouse and human EST databases; B7h and B7-H3 amino acid sequences were used for the screening. B7-H4 contains one immunoglobulin (Ig) Ig-like V and one Ig-like C domain in the extracellular domain, a transmembrane domain, and an intracellular domain. B7-H4 is expressed in antigen presented cell (APC), and its expression is downregulated in B cells after different stimulus (LPS, IL-4, anti-IgM, and anti-CD40). B7-H4 inhibits cell-cycle progression, proliferation, and cytokine production in CD4 and CD8 T cells. Experimental interference of B7-H4 signaling exacerbates autoimmune diseases such as rheumatoid arthritis and multiple sclerosis. In Type 1 diabetes (T1D) the presence of activated islet-specific T cells is the key feature of the associated autoimmune condition. B7-H4-Ig fusion protein inhibits the proliferation of islet-specific T1D T cell clones obtained from patients. In addition, T1D is considerably reduced in diabetes-susceptible NOD mice treated with B7-H4-Ig protein. High levels in sera of soluble B7-H4 have been detected patients with T1D. The metalloproteinase nardilysin (NRD1) was identified as the enzyme that mediates B7-H4 shedding and the potential cleavage site was described as K246 RRS249. B7-H4 is overexpressed in human cancers and frequently associated with negative clinical outcome. B7-H4 chimeric antigen receptor (CAR) T cell therapy was applied in a mouse model; B7-H4 CAR T cells lysed B7-H4+ targets and presented antitumor activity in vivo against B7-H4+ human ovarian tumor xenografts. |
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| Size | 25 µg |
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| Concentration | n/a |
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| Applications | BA |
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| Other Names | B7 Homolog 4, B7 Superfamily Member 1 (B7S1), Immune Costimulatory Protein B7-H4 (B7-H4), V-Set Domain Containing T Cell Activation Inhibitor 1 (VCTN1), T Cell Costimulatory Molecule B7x (B7X) |
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| Gene, Accession, CAS # | Gene ID: 79679 |
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| Catalog # | 774604 |
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| Order / More Info | Recombinant Human B7-H4-Fc Chimera (carrier-free) from BIOLEGEND |
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| Product Specific References | n/a |
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