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| Product Name | Nerve Growth Factor Receptor, Fc Chimera, Human |
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| Description | Purity ~95% (SDS-PAGE). Nerve growth factor (NGF) receptor, also known as p75NTR, is a low affinity NGF receptor. It binds with equal affinity neurotrophins such as beta NGF, BDNF, NT-3 and NT-4. NGF receptors mediate signaling of neurotrophins for neuronal survival, apoptosis, neurite outgrowth and synaptic plasticity. These receptors are also thought to play a role in neurogenerative diseases such as Alzheimers disease. The NGF receptor is a type I transmembrane glycoprotein (399aa) consisting of a signal peptide (28 aa), an extracellular domain (222aa) which contains four cysteine rich domains responsible for ligand binding, a transmembrane domain (22aa) and a cytoplasmic domain (155aa). Source: Nerve Growth Factor Receptor-Fc Chimera, from human DNA sequence encoding the signal peptide and extracellular domain of human NGF receptor aa1-237 was fused to the Fc region of human IgG1 aa93-330. The chimeric protein was expressed in modified human 293 cells. Molecular Weight: ~65kD-90kD |
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| Size | 15ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Nerve Growth Factor Receptor, Fc Chimera, Human (Low-affinity Nerve Growth Factor Receptor, NGF Receptor, Gp80-LNGFR, p75 ICD, Low Affinity Neurotrophin Receptor p75NTR, p75NTR, CD271) |
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| Gene, Accession, CAS # | SwissProt: P08138 |
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| Catalog # | 215379 |
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| Order / More Info | Nerve Growth Factor Receptor, Fc Chimera, Human from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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