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| Product Name | SCFFbw7 Complex, Active, Recombinant, Human, GST/His-Tag (SCFFbxw7, SCFhCdc4) |
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| Description | Purity ~93% (SDS-PAGE, Coomassie blue staining). The SCF complexes represent the largest family of ubiquitin-protein ligases and mediate the ubiquitination of a broad spectrum of regulatory and signalling proteins in diverse cellular pathways. The SCF consists of three invariant components, Skp1, Cul1, and Rbx1 and an interchangeable subunit, an F-box protein which is responsible for recruiting specific substrates to be ubiquitinated by the SCF. SCFFbw7 mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell division, growth and differentiation, including Cyclin E1, c-Myc, Notch and c-Jun. Mutations have been found in the Fbw7 subunit of SCFFbw7 in various types of human cancers, therefore Fbw7 is considered to be a potent tumour suppressor. Source: Recombinant corresponding to complex of N-terminal GST-tagged, recombinant human Fbw7 full length, N-terminal 6His-tagged, recombinant human Skp1 full length, N-terminal 6His-tagged, recombinan |
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| Size | 10ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | Accession: NM_033632, NM_170679, NM_003592, NM_014248 |
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| Catalog # | 29606 |
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| Order / More Info | SCFFbw7 Complex, Active, Recombinant, Human, GST/His-Tag (SCFFbxw7, SCFhCdc4) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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