| 产品详情 |
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| Antigenic Specificity | FAK |
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| Clone | W16060A |
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| Host Species | Rat |
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| Reactive Species | human |
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| Isotype | IgG2a, κ |
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| Format | purified |
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| Size | 100 µg |
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| Concentration | n/a |
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| Applications | Western Blot (WB), Immunofluorescence Microscopy (IF) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Purified anti-FAK. FAK (Focal adhesion kinase) is an intracellular, highly conserved, nonreceptor tyrosine kinase encoded by PTK2 located on human chromosome 8q24.3. It is ubiquitously expressed in all cells and was initially identified in v-Src transformed chicken embryo fibroblasts. FAK is a multi-functional regulator of cell signaling within the tumor microenvironment. During development and in various tumors, FAK promotes cell motility, survival and proliferation through kinase-dependent and -independent mechanisms. FAK is associated with many aspects of metastasis such as adhesion, migration and invasion. FAK is overexpressed and activated in a variety of cancers including ovary, colon, breast, lung, thyroid, head and neck, liver, pancreatic and esophageal and is correlated with poor survival rates. Small molecule FAK inhibitors are emerging as promising chemotherapeutics, as FAK inhibition in mouse models prevents tumor growth, metastasis, vascular permeability, and angiogenesis. |
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| Immunogen | Partial human FAK (701-950 a.a.) expressed in E. coli. |
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| Other Names | Focal adhesion kinase 1, FAK1, FRNK, Protein-tyrosine kinase 2, PTK2 |
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| Gene, Accession # | Gene ID: 5747 |
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| Catalog # | 694002 |
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| Price | |
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| Order / More Info | FAK Antibody from BIOLEGEND |
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| Product Specific References | n/a |
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