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| Product Name | Recombinant Mouse TACI-Fc Chimera (carrier-free) |
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| Description | Transmembrane activator and calcium-modulator and cytophilin ligand interactor (TACI) is a TNFR family member molecule and is part of the so-called BAFF system. This includes two ligands: B cell-activating factor of the TNF family (BAFF) and a proliferation-inducing ligand (APRIL), and three receptors: BAFFR (TNFRSF13C), TACI (TNFRSF13B), and B cell maturation Ag (BCMA or TNFRSF17). BAFF binds the three receptors, while APRIL binds TACI and BCMA. TACI is constitutively expressed on naïve B cells and is upregulated on activated B cells. TACI levels are severely reduced in newborn mice B cells compared with those of adult mice, and newborn B cells do not secret Igs when they are stimulated with BAFF or APRIL. This reduced TACI expression might be responsible for the irresponsiveness of newborn B cells to T cell independent type II antigens such as bacterial capsular polysaccharides. |
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| Size | 500 µg |
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| Concentration | n/a |
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| Applications | BA |
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| Other Names | TNFRSF13B |
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| Gene, Accession, CAS # | Gene ID: 57916 |
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| Catalog # | 577708 |
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| Order / More Info | Recombinant Mouse TACI-Fc Chimera (carrier-free) from BIOLEGEND |
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| Product Specific References | n/a |
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