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| Product Name | Recombinant Human PDGF-BB (carrier-free) |
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| Description | PDGF-BB is a mitogen initially identified as simian sarcoma viral oncogene homolog. It belongs to the PDGF family which includes five members, PDGF-AA, PDGF-BB, PDGF-AB, PDGFCC, and PDGF-DD. PDGF-AA, AB, and BB dimers are processed intracellularly and secreted as active dimers that readily activate PDGF receptors (PDGFRs). PDGF CC and DD are secreted as full-length, latent dimers, and the proteolytic removal of a CUB domain is required for the growth factor domain of PDGF CC or DD to activate the PDGF receptors. PDGF-BB exerts its biological functions through the activation of dimeric receptors made up of two structurally similar protein-tyrosine kinase receptor subunits (αα-, αβ-, or ββ-PDGFR). PDGF has been characterized as a chemoattractant for vascular smooth muscle cells from both sheep and humans and also for canine tracheal myocytes. In cutaneous remodelling, studies ex vivo revealed that PDGF-BB is a mitogen and chemoattractant for dermal fibroblast. Abnormalities of PDGFR/PDGF are thought to contribute to a number of human diseases, and especially malignancy. Autocrine signalling as a consequence of PDGF-B overexpression is clearly implicated in the pathogenesis of dermatofibrosarcoma protruberans (DFSP). |
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| Size | 500 µg |
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| Concentration | n/a |
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| Applications | BA |
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| Other Names | Simian sarcoma viral oncogene homolog, v-SIS, SSV, SIS, c-sis, PDGF2 |
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| Gene, Accession, CAS # | Gene ID: 5159 |
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| Catalog # | 577308 |
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| Order / More Info | Recombinant Human PDGF-BB (carrier-free) from BIOLEGEND |
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| Product Specific References | PubMed: 21808062 |
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