| 产品详情 |
| Edit |   |
|---|
| Product Name | ARRY-520 |
|---|
| Description | A potent Eg5 inhibitor (IC50 = 6 nM); selective for Eg5 over a panel of 8 kinesins (IC50s = >100 µM) and a panel of 224 kinases at 10 µM; induces time-and dose-dependent cell death in HL-60, Jurkat, OCI-AML3, U937, and MOLM-13 leukemic cells; induces cell cycle arrest at the G2/M phase in a p53- and XIAP-independent manner in OCI-AML3 cells; inhibits blast colony formation of bone marrow samples derived from human AML patients; completely eliminates tumors in the RPMI-8226 multiple myeloma and HL-60 and MV4-11 AML mouse xenograft models at 20 mg/kg per day , |
|---|
| Size | 10 mg |
|---|
| Concentration | n/a |
|---|
| Applications | n/a |
|---|
| Other Names | Filanesib |
|---|
| Gene, Accession, CAS # | CAS: 885060-09-3 |
|---|
| Catalog # | 21883-10 |
|---|
| Price | |
|---|
| Order / More Info | ARRY-520 from CAYMAN CHEMICAL COMPANY |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|