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| Product Name | Osteocalcin, Bovine (Bone-Gla-Protein, BGP) |
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| Description | Highly purified (>95% by SDS-PAGE). Osteocalcin, also known as Bone-Gla-Protein (BGP), is a single chain (Mr=5800) vitamin K dependent protein produced by osteoblasts. It is found in high concentrations in bone (1-4). Post-translational modification by a vitamin K dependent carboxylase produces three g-carboxyglutamic acid residues at positions 17, 21 and 24. The mature protein contains 49 amino acids and a single intrachain disulfide bond joining Cys23 to Cys29. The secondary structure is highly calcium dependent and contains 14% alpha-helix, 20% beta-sheet and 67% random form in the presence of calcium, and 1% alpha-helix, 20% beta-sheet and 79% random form in the absence of calcium (4). BGP binds to phospholipid vesicles in the presence of calcium ions (Kd=6 x 10e-6 M) (5). BGP also binds hydroxyapatite and is an efficient inhibitor of hydroxyapatite seeded crystal growth, suggesting a regulatory role in bone mineralization (6). Although the fundamental role of BGP in vivo remains e |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | ELISA |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | O8060-11 |
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| Order / More Info | Osteocalcin, Bovine (Bone-Gla-Protein, BGP) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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