| 产品详情 |
| Edit |   |
|---|
| Product Name | Recombinant Mouse IL-5 (carrier-free) |
|---|
| Description | IL-5 is a homodimeric glycoprotein that was initially identified by its ability to support the in vitro growth and differentiation of mouse B cells and eosinophils. IL-5 induces eosinophil progenitor cell proliferation, terminal differentiation, and activation. In animal models of allergic diseases or helminth infection, IL-5 induces a massive proliferation of eosinophil progenitors in the bone marrow, promotes eosinophil recruitment with eotaxins, and prolongs eosinophil survival in local tissues. IL-5 regulates genes involved in the B cell terminal differentiation. IL-5 induces CD38-activated splenic B cells to differentiate into immunoglobulin M-secreting cells and go through m to g1 class switch recombination at the DNA level, resulting in immunoglobulin G1 (IgG1) production. IL-5 binds the IL-5R complex, which consists of an IL-5Rα chain specific for IL-5 and a common β-chain that is shared by the receptors for IL-3 and GM-CSF. The alpha subunit is required for ligand-specific binding whereas association with the beta subunit results in increased binding affinity. IL-5 plays important roles in the pathogenesis of asthma, hypereosinophilic syndromes, and eosinophil-dependent inflammatory disease. |
|---|
| Size | 10 µg |
|---|
| Concentration | n/a |
|---|
| Applications | BA |
|---|
| Other Names | Interleukin-5, EDF, Eo-CSF, BCGF-2, BCDF-m, IgA-EF, TRF-1 |
|---|
| Gene, Accession, CAS # | Gene ID: 16191 |
|---|
| Catalog # | 581502 |
|---|
| Price | |
|---|
| Order / More Info | Recombinant Mouse IL-5 (carrier-free) from BIOLEGEND |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|