产品名称 Recombinant Mouse IL-6 (carrier-free) from BIOLEGEND
产品货号 575702
产品价格 现货询价,电话:010-67529703
产品规格 10 µg
产品品牌 BIOLEGEND
产品概述
产品详情
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Product NameRecombinant Mouse IL-6 (carrier-free)
DescriptionIL-6 is a multifunctional cytokine that can regulate various immune and inflammatory responses. Several studies have suggested a crucial role for IL-6 in angiogenesis. The use of mice deficient in IL-6 (-/-) demonstrated a critical role for this protein in a mouse model of lung angiogenesis. IL-6 has been shown to cause proliferation and migration of systemic endothelial cells in culture (1). The classical responsiveness to IL-6 is governed by a receptor complex consisting of two membrane-bound subunits, an 80-kD cognate chain (IL-6R), and a ubiquitously expressed 130-kD β-chain receptor (gp130) which acts as the universal signal-transducing element for all IL-6 family cytokines (2). Alternatively, IL-6 regulation of leukocyte trafficking relies upon signaling via its soluble IL-6R (termed IL-6 trans-signaling) (3). IL-6 plays a major role in regulating neutrophil clearance during acute peritoneal inflammation; as a result of specific down-regulation of neutrophil-attracting chemokine (CXCL1/KC) production (4). IL-6 is a key factor that reciprocally regulates Th17 and Foxp3(+) Treg differentiation by inhibition of TGF-beta induced Foxp3 and induction of RORgammat, a Th17 lineage-specific transcription factor (5).
Size10 µg
Concentrationn/a
ApplicationsBA
Other NamesInterleukin-6, Interferon-b2, BSF-2, CDF, HSF, HPGF
Gene, Accession, CAS #Gene ID: 16193
Catalog #575702
Price
Order / More InfoRecombinant Mouse IL-6 (carrier-free) from BIOLEGEND
Product Specific ReferencesPubMed: 20530256,21321188,21771795,22219321,24944284
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