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| Product Name | Recombinant Rat Erythropoietin (EPO) (carrier-free) |
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| Description | Rat Erythropoietin was cloned in 1992, and it has a 79% and 95% homology with human and mouse EPOs, respectively. EPO is a glycoprotein composed of 40-60% carbohydrates, and its molecular weight varies from 30-34 kD depending on the carbohydrate percentage. Hypoxia induces erythropoiesis, and hypoxia inducible factor (HIF) is directly involved in EPO expression. HIF is a heterodimeric transcription factor (HIF-1α, HIF-2α, and beta subunits), and it is regulated by HIF-prolyl hydroxylase (HIF-PH) that hydroxylates the alpha subunits targeting them for ubiquitination and subsequent degradation. HIF-PH is a sensor of levels of iron, oxygen, and metabolic activity. High levels of HIF protein induce EPO production in the kidney and liver, and mobilization of iron to support erythropoiesis. EPO binds to EPOR, and transcripts of this receptor have been detected in non-erythroid precursors such as endothelial cells and renal proximal epithelial cells; nevertheless, it has been published that functional erythropoietin receptor is not detected in endothelial, cardiac, neuronal, and renal cells. Several transcriptions factors play a role in the expression of EPOR such as GATA1, Friend of GATA (Fog1), and the erythroid specific factor SCL/Tal1. EPO has been used to treat anemia associated with chronic kidney disease, cancer patients on chemotherapy, and as an antiviral HIV therapy. |
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| Size | 10 µg |
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| Concentration | n/a |
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| Applications | BA |
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| Other Names | n/a |
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| Gene, Accession, CAS # | Gene ID: 24335 |
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| Catalog # | 592302 |
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| Order / More Info | Recombinant Rat Erythropoietin (EPO) (carrier-free) from BIOLEGEND |
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| Product Specific References | n/a |
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