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| Product Name | Recombinant Mouse Syndecan-2 (carrier-free) |
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| Description | Syndecan-2, previously known as fibroglycan, is a member of the syndecan family of Type 1 transmembrane proteins carrying heparan sulfate and chondroitin sulfate glycosaminoglycans. The syndecan family consists of four transmembrane proteoglycans divided into two subfamilies (Syndecan -1 , -3 and Syndecan-2 ,- 4) based on their sequence homology. The four syndecans have conserved cytoplasmic domains which enables them to associate with cytoskeletal proteins and signaling molecules. The cytoplasmic tail of Syndecan-2 has both serine and tyrosine phosphorylation sites. Non-covalent homodimerization of Syndecan-2 is dependent on the transmembrane domain. Syndecan-2 is expressed in endothelial, mesenchymal, carcinoma cells, and is the predominant syndecan expressed during embryonic development. It functions as a co-receptor for enzymes, growth factors, and cytokines, and contributes to the formation of cytokine gradients through extracellular shedding. Syndecan-2 interacts with high affinity receptors and integrins to modulate intracellular signaling. Syndecan is also involved in matrix assembly and remodeling. It controls laminin and fibronectin matrix assembly into a fibrillar matrix. |
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| Size | 25 µg |
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| Concentration | n/a |
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| Applications | BA |
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| Other Names | SDC2, Synd2, Hspg1, Fibroglycan |
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| Gene, Accession, CAS # | Gene ID: 15529 |
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| Catalog # | 759404 |
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| Order / More Info | Recombinant Mouse Syndecan-2 (carrier-free) from BIOLEGEND |
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| Product Specific References | n/a |
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