| 产品详情 |
| Edit |   |
|---|
| Product Name | Recombinant Mouse sTNF-RI (TNFRSF1A) (carrier-free) |
|---|
| Description | The biological effects of TNF are mediated by two cell surface TNF receptors, TNF-RI and TNF-RII. TNF-RI and TNF-RII are structurally related but functionally distinct. Also, TNF-RI is widely expressed on most cells whereas TNF-RII is more restricted and is primarily expressed in hematopoietic cells and cells of the immune system. Most of the biological effects of TNF are mediated by TNF-RI. TNF-RI can be activated by both membrane bound and soluble TNF. TNF-RI contains a cytoplasmic death domain which mediates the induction of apoptosis or NF-kB activation. After TNF binding, the death domain can recruit TRADD which in turn will further recruit FADD or TRAF2. FADD will initiate apoptosis signal by mediating caspase-8 activation. TRAF2 will exert survival effects through NF-kB activation which will induce the expression of antiapoptotic genes such as BcL-2. Like TNFα, TNF-RI and TNF-RII also undergo ectodomain shedding. The resulting soluble TNF-RI and TNFR-II can bind TNF with high affinity and modulate TNF effects. TNF-RI shedding is catalyzed by TNF-alpha converting enzyme (TACE). Human soluble TNF-RI is constitutively released in the general circulation and its level increases in many diseases including rheumatoid arthritics and inflammatory bowel disease. Impaired TNF-RI shedding due to TNF-RI mutation will cause TNF receptor associated periodic syndrome (TRAPS). TNF-RI shedding also plays a protective role in TNF-alpha sensitization of hepatocytes to Fas-mediated death. |
|---|
| Size | 25 µg |
|---|
| Concentration | n/a |
|---|
| Applications | BA |
|---|
| Other Names | Tumor necrosis factor receptor 1, p75TNFR, cd120a, TNFRSF1A, Tnfrsf1, FPF, TNF-R, TNF-R-I, TNF R1, TNF-R55, TNF-alphaR1, TNFAR, TNFR60, TNFRI |
|---|
| Gene, Accession, CAS # | Gene ID: 21937 |
|---|
| Catalog # | 763204 |
|---|
| Price | |
|---|
| Order / More Info | Recombinant Mouse sTNF-RI (TNFRSF1A) (carrier-free) from BIOLEGEND |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|