| 产品详情 |
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| Product Name | CBL0137 |
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| Description | CBL0137 is a metabolically stable curaxin that activates p53 (EC50 = 0.37 µM) and inhibits NF-κB (EC50 = 0.47 µM). It functionally inactivates the facilitates chromatin transcription complex (FACT), driving the effects on p53 and NF-κB and promoting cancer cell death. CBL0137 has broad anticancer activity in mice when administered orally, eradicates drug-resistant cancer stem cells, and potentiates efficacy of gemcitabine (Cat. No.1759 in preclinical models of pancreatic cancer. MW: 336.4. Purity ≥98% by HPLC |
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| Size | 25 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 1,1'-[9-[2-[(1-methylethyl)amino]ethyl]-9H-carbazole-3,6-diyl]-bis-ethanone; Curaxin 137 |
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| Gene, Accession, CAS # | CAS: 1197996-80-7 |
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| Catalog # | B2036-25 |
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| Order / More Info | CBL0137 from BIOVISION, INC. |
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| Product Specific References | n/a |
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