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| Product Name | Mitoxantrone dihydrochloride |
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| Description | Type II DNA topoisomerase inhibitor. Disrupts DNA synthesis and repair and induces damage by DNA cross-linking. Also inhibits PIM1 kinase (IC50 = 51 nM). Immunomodulatory, antineoplastic and chemotherapeutic agent. Also USP11 inhibitor (IC50= 3.15 μM). Induces cell death of pancreatic cancer cell lines expressing wild-type BRCA2. Purity 98%. MW (observed): 517.4 |
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| Size | 50 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 1,4-Dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-9,10-anthracenedione dihydrochloride |
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| Gene, Accession, CAS # | CAS: 70476-82-3 |
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| Catalog # | 4250/50 |
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| Order / More Info | Mitoxantrone dihydrochloride from TOCRIS BIOSCIENCE
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| Product Specific References | PubMed: 25402202, 28265007 |
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