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| Product Name | Recombinant Mouse DKK-1 (carrier-free) |
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| Description | DKK-1 (Dickkopf related protein 1) is a member of the Dickkopf family of proteins that include DKK-1, -2, -3,-4, and Soggy. DKK-1 was discovered by its ability to block Wnt signaling during early Xenopus embryogenesis. DKK-1 antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt proteins. DKK-1 forms ternary complex with LRP5/6 and the transmembane protein Kremen1/2, promoting internalization of LRP5/6 and down regulation of Wnt signaling. DKK-1 contains two conserved cysteine-rich domains separated by a linker region. N-terminal cysteine-rich domain is unique to DKKs while C-terminal cysteine-rich domain has a pattern of 10 cysteines similar to colipase fold. DKK-1 binds with LRP6 with high affinity and this interaction is enhanced by Kremens. The interactions between DKK-1 and both LRP6 and Kremens are mediated via C-terminal cysteine-rich domain. DKKs are expressed throughout development and play important role by locally inhibiting Wnt regulated processes such as limb development, somitogenesis, antero-posterior axial patterning, and eye formation. In the adult, DKKs are implicated in bone formation and bone disease, cancer and Alzheimer disease. The balance between Wnt signaling and DKK-1 inhibition is important for bone homeostasis. Increased expressions of DKK-1 are found in lung cancers, esophageal squamous cell carcinomas, and hormone-resistant breast cancers. DKK-1 expression is decreased in malignant melanoma and colorectal cancers. DKK-1 has been shown to partially abrogate Wnt3a dependent inhibtion of alkaline phosphase production in BMP2 stimulated osteoprogenitors. |
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| Size | 10 µg |
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| Concentration | n/a |
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| Applications | BA |
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| Other Names | Dickkopf-related protein 1, DKK1 |
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| Gene, Accession, CAS # | Gene ID: 13380 |
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| Catalog # | 759602 |
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| Order / More Info | Recombinant Mouse DKK-1 (carrier-free) from BIOLEGEND |
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| Product Specific References | n/a |
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