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| Product Name | Recombinant Mouse IHH (carrier-free) |
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| Description | The hedgehog family of morphogens are regulators of cell proliferation, differentiation, and cell-cell communication. They have important roles in organogenesis, spermatogenesis, stem cell maintenance, and oncogenesis. The vertebrate hedgehog family comprises of sonic hedgehog (Shh), Indian hedgehog (IHH or Ihh), and the Desert hedgehog (Dhh). Hedgehog proteins are highly conserved within and across species with mouse and human IHH sharing 100% amino acid identity in the signaling domain, while mouse IHH and Shh share 90% amino acid identity in the N-terminal signaling domain. The C-terminal domain displays an autoproteolysis activity and a cholesterol transferase activity. Both activities result in the cleavage of the full-length protein and covalent attachment of a cholesterol moiety to the C-terminal of the newly generated N-terminal signaling domain. Hedgehogs bind to the patched (PTC) receptor, which functions in the association with smoothened (SMO), to activate the transcription of target genes. In the embryo, IHH is detected in the developing gut, the growth zone of cartilage of developing long bones, epithelium, and the urogenital sinus. IHH is implicated in the endochondral ossification by regulating the balance between the growth and ossification of the developing bones. IHH is also known to induce the expression of parathyroid hormone-related protein (PTHRP). Since it has been shown that the replacement of N-terminal cysteine with two isoleucine residues conferred increased activity of Shh, similar modification was made for IHH. |
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| Size | 100 µg |
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| Concentration | n/a |
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| Applications | BA |
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| Other Names | Indian Hedgehog |
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| Gene, Accession, CAS # | Gene ID: 16147 |
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| Catalog # | 758606 |
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| Order / More Info | Recombinant Mouse IHH (carrier-free) from BIOLEGEND |
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| Product Specific References | n/a |
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