产品名称 DMH-1 from TOCRIS BIOSCIENCE
产品货号 4126/50
产品价格 现货询价,电话:010-67529703
产品规格 50 mg
产品品牌 TOCRIS BIOSCIENCE
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Product NameDMH-1
DescriptionSelective inhibitor of bone morphogenic protein (BMP) type-I receptor activin receptor-like kinase 2 (ALK2) receptor (IC50 = 108 nM [Hao et al., 2010] or 12.6 nM [Mohedas et al., 2013] in in vitro kinase assays). Exhibits 6- and 19-fold selectivity for ALK-2 over ALK-1 and ALK-3, respectively, and no significant inhibition of AMPK, ALK5, KDR (VEGFR-2) or PDGFRβ receptors. Blocks BMP4-induced phosphorylation of Smads 1, 5 and 8 in HEK293 cells. Promotes neurogenesis in human induced pluripotent stem cells (iPSCs) when used in combination with SB 431542 (Cat. No. 1614). Purity 98%. MW (observed): 380.44
Size50 mg
Concentrationn/a
Applicationsn/a
Other Names4-[6-[4-(1-Methylethoxy)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]-quinoline
Gene, Accession, CAS #CAS: 1206711-16-1
Catalog #4126/50
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Order / More InfoDMH-1 from TOCRIS BIOSCIENCE
Product Specific ReferencesPubMed: 23563587, 23928500, 25579684, 25806427, 26110906, 26215036, 26655496, 27320041
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