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| Product Name | Recombinant Mouse IGF-I (carrier-free) |
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| Description | Mouse IGF-I is a member of the IGF family that is comprised of three members: IGF-I, IGF-II, and insulin. IGF-I and IGF-II share approximately 50% similarity with insulin at the amino acid level. Mouse IGF-I is synthesized as a 165 amino acid pre-pro-IGF-I, which includes the signal peptide, the mature protein, and the C-terminal E-peptide; the pro-IGFI possesses a proprotein convertase/furin cleavage site preceding the E-peptide. Pro-IGF-I is processed to the mature, active protein, and this procedure requires glucose regulating protein 94 (GRP94) that possesses chaperone activity towards IGF-I. Deletion of muscle GRP94 impairs muscle and body growth by inhibiting local production of IGF proteins. Seven binding proteins have been described (IGFBP-1 to 7). IGFBPs extend the half life and regulate the availability of IGF-I and IGF-II. It has been described that IGFBP3 is the main circulating binding protein for IGF's; in serum, approximately 75% of circulating IGF-I and IGF-II bind to IGFBP3 and the co-carrier acid labile subunit (ALS). IGF-I binds to three receptors, and the binding to IGFIR promotes cell proliferation, survival, differentiation, and migration. IGF-I is a key factor for muscle growth and repair. Inactivation of IGF-RI in skeletal muscle leads to 10-30% lower mass and delayed regeneration after injury. |
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| Size | 10 µg |
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| Concentration | n/a |
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| Applications | BA |
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| Other Names | Insulin-like growth factor I, somatomedin C, Nonsuppressible insulin-like activity I (NSILA-I), IGF1 |
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| Gene, Accession, CAS # | Gene ID: 16000 |
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| Catalog # | 591402 |
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| Order / More Info | Recombinant Mouse IGF-I (carrier-free) from BIOLEGEND |
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| Product Specific References | n/a |
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