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| Product Name | Recombinant Human L-Selectin (CD62L)-Fc Chimera (carrier-free) |
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| Description | L-selectin, belonging to the selectin/LECAM family, is a type I transmembrane protein, consisted of one C-type lectin domain and EGF-like repeats, followed by a transmembrane region and a short cytoplasmic tail of 17 amino acids. L-selectin gene encodes a protein with a predicted size of 42 kD, but the actual molecular weight is around 70 kD to 120 kD, due to N-linked glycosylation. L-selectin is constitutively expressed on leukocytes. As a homing receptor, L-selectin mediates adhesion and rolling of leukocytes on endothelial cells, in turn leukocytes enter peripheral lymphoid organs via high endothelial venules (HEV). L-selectin also directs leukocytes to inflammation sites. Circulating leukocytes can also tether on adherent leukocytes through the interaction between L-selectin and P-selectin glycoprotein ligand-1 (PSGL-1). L-selectin also interacts with mucins, such as CD34, glycosylated cell adhesion molecule-1 (GlyCAM-1) and podocalyxin. Ligand-induced clustering of L-selectin enhances leukocyte tethering and causes signaling cascade, promoting activation of integrin and mobilizing chemokine receptor on cell surface. To negatively regulate leukocyte recruitment and migration, L-selectin is cleaved by ADAM17, released from cell surface (ectodomain shedding) with functional activity. High level of soluble L-selectin can be detected in human plasma. |
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| Size | 25 µg |
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| Concentration | n/a |
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| Applications | BA |
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| Other Names | SELL, CD62 antigen-like family member L, CD62L, Leukocyte-endothelial cell adhesion molecule 1 (LECAM1), Leukocyte adhesion molecule 1 (LAM-1), Leukocyte surface antigen Leu-8, Lymph node homing receptor, TQ1, gp90-MEL, Lymphocyte antigen 22 (Ly-22) |
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| Gene, Accession, CAS # | Gene ID: 6402 |
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| Catalog # | 772704 |
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| Order / More Info | Recombinant Human L-Selectin (CD62L)-Fc Chimera (carrier-free) from BIOLEGEND |
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| Product Specific References | n/a |
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