| 产品详情 |
| Edit |   |
|---|
| Product Name | CPI-455 |
|---|
| Description | CPI-455 is a potent and selective KDM5A inhibitor (IC50 ~10 nM). It inhibits KDM5A, KDM5B and KDM5C to similar extents but shows substantially weaker potency toward KDM4C and KDM7B (~200- and 770-fold, respectively) and no detectable inhibition of KDM2B, KDM3B or KDM6A. It specifically alters H3K4 methylation in cells and binds at the demethylase active site. CPI-455-mediated KDM5 inhibition leads to a dose-dependent increase in global H3K4me3 in HeLa cells, and the removal of CPI-455 resulted in a rapid reversal of H3K4me3 increases in HeLa cells. MW: 278.31. Purity ≥98% by HPLC |
|---|
| Size | 25 mg |
|---|
| Concentration | n/a |
|---|
| Applications | n/a |
|---|
| Other Names | 6-Isopropyl-7-oxo-5-phenyl-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile |
|---|
| Gene, Accession, CAS # | CAS: 1628208-23-0 |
|---|
| Catalog # | B1881-25 |
|---|
| Price | |
|---|
| Order / More Info | CPI-455 from BIOVISION, INC. |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|