| 产品详情 |
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| Product Name | Loxoribine |
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| Description | A guanosine derivative and an agonist of TLR7; selective for TLR7 over other human TLRs in a cell-based reporter assay at 1 mM; induces proliferation, increases the antibody response to sheep red blood cells, and activates natural killer cell activity against Yac-1 lymphoma cells in murine splenocyte cultures (EC50s = 10-50, 3-20, and 13-22 µM, respectively); increases production of IL-12, IL-23, IL-27, and IL-10 by human MoDCs at 250 µM; loxoribine-treated MoDCs induce higher levels of IL-17 and IFN-γ secretion by co-cultured allogeneic CD4+ T cells compared to control MoDCs; reduces the number of pulmonary metastases in the B16 mouse model of melanoma at 120 mg/kg, an effect enhanced by co-administration of IL-2; exhibits adjuvant activity in mice immunized with a B16 tumor vaccine |
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| Size | 10 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 7-Allyl-8-Oxoguanosine|RWJ 21757 |
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| Gene, Accession, CAS # | CAS: 121288-39-9 |
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| Catalog # | 21186-10 |
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| Price | |
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| Order / More Info | Loxoribine from CAYMAN CHEMICAL COMPANY |
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| Product Specific References | n/a |
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