| 产品详情 |
| Edit |   |
|---|
| Antigenic Specificity | alpha-Synuclein Phospho (Ser12) |
|---|
| Clone | P-syn/81A |
|---|
| Host Species | Mouse |
|---|
| Reactive Species | human |
|---|
| Isotype | IgG2a, κ |
|---|
| Format | biotin conjugate |
|---|
| Size | 100 µg |
|---|
| Concentration | n/a |
|---|
| Applications | IHC-P |
|---|
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
|---|
| Description | Biotin anti-α-Synuclein Phospho (Ser129). α-synuclein is expressed principally in the nervous system, but it is also produced in other tissues, including the skin. In the brain, the protein is primarily neuronal, but it is also present in glia. Neuronal α-synuclein is concentrated in presynapt ic nerve terminals, interacts with plasma membrane phospholipids, and is also present in nuclei and mitochondria. At least three isoforms of α-synuclein are produced through alternative splicing. The most common isoform is a 140 amino acid-long transcript. Other isoforms includes, a-synuclein-126, lacking residues 41-54; and α-synuclein-112, which lacks residues 103-130. α-synuclein’s physiological role is poorly understood, but the protein has been implicated in regulating dopamine release and transport, synaptic vesicle clustering, and functioning as a SNARE-complex chaperone. α-synuclein fibrils are a major component of the intracellular Lewy bodies that are associated with Parkinson's disease, Lewy body dementia, and multiple system atrophy. α-synuclein is phosphorylated at low levels under normal physiological conditions whereas the majority of the protein is phosphorylated in Lewy bodies at S129. |
|---|
| Immunogen | This monoclonal antibody was raised against a synthetic peptide corresponding to amino acids 124 - 134 of α-synuclein, phosphorylated at Serine 129, and conjugated to KLH via a C-terminal Cysteine. |
|---|
| Other Names | Synuclein alpha-140, non-A4 component of amyloid, alpha-synuclein, isoform NACP140, non-A beta component of AD amyloid Parkinson disease (autosomal dominant, Lewy body) 4 |
|---|
| Gene, Accession # | Gene ID: 6622 |
|---|
| Catalog # | 825704 |
|---|
| Price | |
|---|
| Order / More Info | alpha-Synuclein Phospho (Ser12) Antibody from BIOLEGEND |
|---|
| Product Specific References | PubMed: 25122523 |
|---|
| 产品资料 |
|
|