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| Product Name | Recombinant Human Vitronectin (carrier-free) |
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| Description | Vitronectin was first described as a serum-spreading factor that supported the attachment and spreading of cells onto glass. Vitronectin is a large glycoprotein found in blood and the extracellular matrix. It is a multifunctional protein that mediates cell-to-substrate adhesion, inhibits the cytolytic action of the terminal complement cascade in vitro, and binds to several serine protease inhibitors of the serpin family. Vitronectin is mainly synthesized in the liver and circulates primarily in monomeric form, but can undergo conformational change to a structure that forms disulfide linked multimers. The vitronectin molecule contains Somatomedin-B domain (SMB), four hemopexin domains, and the carboxyl-terminal end which has multiple sites and functions. The SMB domain mediates interaction with Serpine1/PAI1 and the heparin-binding domain at the carboxyl-terminal end mediates interaction with insulin. The carboxyl-terminal end also contains a plasminogen binding site, a glycosaminoglycan binding site, and a second PAI-1 binding site. The heparin binding site also mediates complement factor C7, C8, or C9 binding. Vitronectin’s ablility to bind platelet glycoproteins and mediate platelet adhesion and aggregation at sites of vascular injuries has made it an important mediator in the pathogenesis of coronary atherosclerosis. |
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| Size | 500 µg |
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| Concentration | n/a |
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| Applications | BA |
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| Other Names | VTN, VN, Serum-spreading factor, Complement S-protein, Somatomedin B, V75 |
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| Gene, Accession, CAS # | Gene ID: 7448 |
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| Catalog # | 757708 |
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| Order / More Info | Recombinant Human Vitronectin (carrier-free) from BIOLEGEND |
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| Product Specific References | n/a |
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