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| Product Name | LEGEND MAX™ Human Soluble CTLA-4 ELISA Kit with Pre-coated Plates |
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| Description | CTLA4 (Cytotoxic T-Lymphocyte Antigen 4), also known as CD152, is a protein that plays an important regulatory role in the immune system. CTLA4 is expressed on the surface of Helper T cells and transmits an inhibitory signal to T cells. Mutations in the CTLA4 gene have been associated with various autoimmune diseases, such as systemic lupus erythematosus, insulin-dependent diabetes mellitus, and other autoimmune diseases. A recently identified novel transcript of the CTLA-4 gene that may represent a native soluble form of CTLA-4 (sCTLA-4) showed that eleven of twenty patients with autoimmune thyroid disease (ATD ) had a high concentration of sCTLA-4, whereas only 1 of 30 apparently healthy volunteers contained measurable levels. sCTLA-4 immunoreactivity was inhibited by its binding to B7.1, suggesting that sCTLA-4 is a functional receptor. sCTLA4 also plays a role in the initial immune response to infection of immune cells by HIV, along with the CD-1 pathway and others. The BioLegend Human Soluble CTLA-4 LEGEND MAX™ ELISA kit is a Sandwich Enzyme-Linked Immunosorbent Assay (ELISA) with 96 well microtiter strip plates that are pre-coated with a capture antibody. This ELISA kit is specifically designed for the accurate quantitation of sCTLA-4 from cell culture supernatant, serum, plasma or other biological fluids. They are analytically validated and provide ready to use reagents. |
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| Size | 1 Pre-coated Plate |
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| Concentration | ELISA |
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| Applications | n/a |
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| Other Names | Cytotoxic T-lymphocyte-associated protein 4 (CTLA-4), CD152, GSE, GRD4, ICOS, IDDM12, CELIAC3, CTLA4 Precoated ELISA Kit |
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| Gene, Accession, CAS # | Gene ID: 1493 |
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| Catalog # | 437407 |
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| Order / More Info | LEGEND MAX™ Human Soluble CTLA-4 ELISA Kit with Pre-coated Plates from BIOLEGEND |
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| Product Specific References | n/a |
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