| 产品详情 |
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| Antigenic Specificity | LAT |
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| Clone | LAT1111 |
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| Host Species | Mouse |
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| Reactive Species | human |
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| Isotype | IgG1 |
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| Format | purified |
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| Size | 100 µg |
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| Concentration | n/a |
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| Applications | Western Blot (WB), Intracellular Staining for Flow Cytometry (ICFC), IP |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Purified anti-LAT. LAT (linker for activation of T-cells) is a 36 kD phospho-tyrosine adaptor protein containing SH2 domains and a CVRC motif. Two LAT isoforms have been reported with approximate molecular weights of 36 kD and 38 kD. LAT is localized to lipid rafts, and is also a potential type III transmembrane protein, thought to be expressed in the juxtanuclear intracellular compartment. LAT links TCR engagement to Ras-MAPK activation, Ca2+ flux, IL-2 expression and is required for T-cell development. LAT is phosphorylated when activated by TCR cross-linking, where it recruits signaling molecules. LAT activation can be prevented by polyunsaturated fatty acids. LAT is modified by ZAP-70 and Syk phosphorylation and can also be palmitoylated. LAT has been reported to be associated with Grb2, Gads, Grap, PLC-γ1, p85 subunit PI3K, ZAP-70, Syk, Itk, Vav, SLP-76, and cbl. |
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| Immunogen | Partial recombinant protein (cytoplasmic domain of human LAT) |
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| Other Names | Linker for activation of T-cells, 36 kD phospho-tyrosine adaptor protein |
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| Gene, Accession # | Gene ID: 27040 |
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| Catalog # | 623902 |
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| Price | |
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| Order / More Info | LAT Antibody from BIOLEGEND |
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| Product Specific References | n/a |
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