| 产品详情 |
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| Antigenic Specificity | LAT |
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| Clone | 11B.12 |
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| Host Species | Mouse |
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| Reactive Species | mouse, human |
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| Isotype | IgG1, κ |
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| Format | purified |
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| Size | 100 µg |
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| Concentration | n/a |
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| Applications | Western Blot (WB), IP |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Purified anti-LAT. LAT is a transmembrane molecule that mediates signaling following the engagement of a number of cell surface receptors including TCR during mature T cell activation, pre-TCR during T cell development, Fc RIII on NK cells, and FcεRI on mast cells.LAT is multiply phosphorylated on tyrosines by ZAP-70 and Syk, which leads to downstream effects that include release of intracellular calcium, PKC activation, MAPK activation and cytoskeletal reorganization.Palmitoylation of LAT is required for its localization to lipid rafts and efficient phosphorylation. |
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| Immunogen | GST fusion protein corresponding to residues 31-233 of human LAT, cytoplasmic domain. |
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| Other Names | Linker for activation of T cells |
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| Gene, Accession # | Gene ID: 27040 |
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| Catalog # | 641102 |
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| Price | |
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| Order / More Info | LAT Antibody from BIOLEGEND |
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| Product Specific References | n/a |
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| 产品资料 |
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