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| Product Name | Recombinant Mouse PDGF-BB (carrier-free) |
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| Description | PDGF-BB is a mitogen that was initially identified as simian sarcoma viral oncogene homolog. It belongs to the Platelet-Derived Growth Factor (PDGF) family which includes five members: PDGF-AA, PDGF-BB, PDGF-AB, PDGF-CC, and PDGF-DD. PDGF-AA, AB, and BB dimers are processed intracellularly and secreted as active dimers that readily activate PDGF receptors (PDGFRs). PDGF-CC and PDGF-DD are secreted as full-length, latent dimers. The proteolytic removal of a CUB domain is required for the growth factor domain of PDGF-CC or PDGF-DD in order to activate the PDGFRs. PDGF-BB exerts its biological functions through the activation of dimeric receptors that are made up of two structurally similar protein-tyrosine kinase receptor subunits (αα-, αβ-, or ββ-PDGFR). PDGF has been characterized as a chemoattractant for vascular smooth muscle cells (VSMCs) from sheep and humans and for canine tracheal myocytes as well. The migration of VSMCs is critical for the maturation of nascent vessel sprouts during angiogenesis. PDGF-BB induces VSMC dedifferentiation by the down regulation of contractile protein markers and the up regulation of MMP-2. In cutaneous remodeling, studies ex vivo revealed that PDGF-BB is a mitogen and chemoattractant for dermal fibroblasts. Abnormalities of PDGFR/PDGF are thought to contribute to a number of human diseases, especially malignancy. Autocrine signaling is a consequence of PDGF-BB overexpression, which is clearly implicated in the pathogenesis of dermatofibrosarcoma protruberans (DFSP). |
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| Size | 100 µg |
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| Concentration | n/a |
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| Applications | BA |
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| Other Names | Simian sarcoma viral oncogene homolog, v-SIS, SSV, SIS, c-sis, PDGF2 |
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| Gene, Accession, CAS # | Gene ID: 18591 |
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| Catalog # | 558806 |
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| Order / More Info | Recombinant Mouse PDGF-BB (carrier-free) from BIOLEGEND |
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| Product Specific References | n/a |
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