| 产品详情 |
| Edit |   |
|---|
| Product Name | True-Nuclear™ One Step Staining Human Treg Flow™ Kit (FOXP3 Alexa Fluor® 488/CD25 PE/CD4 PerCP) |
|---|
| Description | FOXP3 is a 50-55 kD transcription factor, also known as Forkhead box protein P3, Scurfin, JM2, or IPEX. It is proposed to be a master regulatory gene and more specific marker of T regulatory cells than most cell surface markers (such as CD4 and CD25). Transduced expression of FOXP3 in CD4+/CD25- cells has been shown to induce GITR, CD103, and CTLA4 and impart a T regulatory cell phenotype. FOXP3 is mutated in X-linked autoimmunity-allergic dysregulation syndrome (XLAAD or IPEX) in humans and in scurfy mice. Overexpression of FOXP3 has been shown to lead to a hypoactive immune state suggesting that this transcriptional factor is a central regulator of T cell activity. In human, unlike in mouse, two isoforms of FOXP3 have been reported: one (FOXP3) corresponding to the canonical full-length sequence; the other (FOXP3 δ2) lacking exon 2. The 206D antibody recognizes human FOXP3 epitope in the region of amino acids 105-235. |
|---|
| Size | 25 tests |
|---|
| Concentration | Flow Cytometry (FC), Intracellular Staining for Flow Cytometry (ICFC) |
|---|
| Applications | n/a |
|---|
| Other Names | n/a |
|---|
| Gene, Accession, CAS # | Gene ID: 50943 |
|---|
| Catalog # | 320127 |
|---|
| Price | |
|---|
| Order / More Info | True-Nuclear™ One Step Staining Human Treg Flow™ Kit (FOXP3 Alexa Fluor® 488/CD25 PE/CD4 PerCP) from BIOLEGEND |
|---|
| Product Specific References | PubMed: 16818678,17577038,17644734,17954571,18156502,18456875,18523152,18641304,18690669,19066178,19240164,19849846,20053943,24838938,25712684 |
|---|
| 产品资料 |
|
|